Researchers reveal a ground-breaking discovery that explains the origins and associations between various neurological ailments, such as multiple sclerosis, autism, and even Alzheimer’s.

A remarkable new scientific discovery has put to shame decades of neurological learning and teaching, as the team of researchers from the University Of Virginia School Of Medicine reveal how the brain is directly linked with the immune system with the help of certain vessels that modern science simply wasn’t even aware existed. The researchers revealed that vessels like these could have easily gone undetected because the lymphatic system has always overshadowed their presence by mapping out its existence throughout the body without any external assistance.

This powerful discovery is a significant scientific breakthrough that sheds light on the effects and treatments of countless neurological ailments, such as multiple sclerosis and various types of arthritis. Previously, modern science and experts were finding it difficult to determine ways to examine the immune responses generated by the brain, and understanding why patients suffering from neurological ailments, like multiple sclerosis, suffered from immune attacks. With this new discovery, experts can understand these dilemmas with a mechanistic approach. And this is primarily because the human brain is similar to every other tissue that is linked with the peripheral immune system via the meningeal lymphatic vessels. This brings about a dramatic change in how modern science used to understand the mechanisms of neuro-immune interactions.

Scientists and neurological experts always believed that this is an esoteric concept that simply cannot be debated or studied deeply. But now, we can engage in this mechanistic discourse and ask more insightful questions. It is widely believed that each and every single neurological ailment comes with an immune component attached to its existence, and this is why it is thought that these vessels have a detrimental role to play. It is extremely difficult to conjure up the idea that these vessels were not associated in the onset of any neurological ailment that features immune components.

Immune System Anatomy and Physiology
Salk Institute

Ground-Breaking New Revelation about the Human Body

When this new discovery was shared amongst other neuroscience experts and researchers, they were left dumbfound by the fact that this one basic result will have far-reaching consequences, primarily starting from changing how the human brain is described in textbooks across the globe.

Researchers have never believed in the existence of a lymphatic system associated with the central nervous system, and it was evident from the very first observation. The researchers had to conduct countless studies afterwards to increase the validity of their results, and it is now believed that this discovery is all set to completely alter the fundamentals of how the central nervous system is viewed, along with its relationship with the immune system.

Even though many neurological researchers had extremely sceptical responses towards these findings, they simply didn’t want to believe the fact that there are still certain structures within the brain and body that modern science has not yet revealed. Naturally, all researchers are firmly grounded to the belief that the human body has been fully mapped out, and discoveries of this particular nature ended occurring in the 19th century. Evidently, these discoveries have not ended and continue to stun us all across the globe.

Extremely Overshadow and Well Hidden

The findings of Antoine Louveau, a celebrated postdoctoral fellow at the Kipin’s laboratory, paved the way for this ground-breaking discovery. Basically, Louveau created a technique to mount the meninges of a mouse, which are basically the membranes that shroud the brain, so they could be examined entirely in one single slide. This led to the discovery of these vessels.

Immune Cells in the Brain
University of Virginia Health System

The process was simple and easy, and it all just depended on one final mechanism: the researchers managed to treat the meninges inside the skullcap, and therefore, the tissue remained intact and restored in its natural physiological state, and then, it was dissected. If the researchers had attempted any other technique, the results simply would not have been the same.

Upon examining these vessel that are patterns to highlight the distribution of the immune cells across the slides, Louveau examined the lymphatic vessels and it was there where he found these vessels to exist. It was as if the impossible had turned to reality, and a dumbstruck Antoine Louveau began calling out his colleagues to examine the stunning discovery he had just made.

Researchers are still attempting to understand how the lymphatic vessels connected to the brain managed to stay hidden and undetected for such a long time, and they believe this is primarily because they are extremely well hidden. The researchers highlighted that these vessels followed a major blood vessel all the way into the sinuses, which tends to be one of the most difficult body parts to take pictures of. It is so nearly located to the blood vessel, which makes it easy for them to pass without being detected.

It was extremely important to capture live imaging of these vessels in order to explain their functioning, which is why the team had to collaborate with Tajie Harris, a renowned PhD and assistant professor of neuroscience. Along with Harris and the remarkable surgical talents of Igor Smirnov, the researchers managed to successfully undertake the highly critical of providing this ground-breaking study some imaging evidence.

Alzheimer’s, Autism, Multiple Sclerosis and other Neurological diseases

The unexpected discovery of the existence of these lymphatic vessels has triggered countless dilemmas and questions that require explains about both, the functions of the human brain and the ailments that tend to affect its functioning.

For instance, let’s take a look at the effects of the Alzheimer’s disease. During the onset of Alzheimer’s, the brain experiences a massive build-up of large protein particles. Neurological researchers believe that these particles tend to build-up within the brain because the vessels are unable to eliminate them effectively. The researchers explained that as the human body continues to age, the vessels tend to alter their shape and functions, and therefore, researchers are faced with the grave need to explore what role these vessels play in the process of aging.

Evidently, there is a wide number of countless neurological ailments, such as autism, and multiple sclerosis, which must be reviewed in the light of this ground-breaking new discovery that modern science managed to stay oblivious to for all these years of innovation and advancements.


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